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Chapter 1 – The Basics, Mitochondria, Apoptosis, Movement, Stem Cells

Mitochondria = Powerhouse

What are Mitochondria & why do I need them?

1. Mitochondria are organelles, or small structures, among the many structures inside the cell.

2. Mitochondria are the energy producing structures in cells. The energy or fuel that mitochondria produce is adenosine triphosphate (ATP). Mitochondrial also have their own DNA (mtDNA), a small portion of the DNA contained in a normal cell in humans. In humans, mitochondrial DNA contains 37 genes, all of which are essential for normal mitochondrial function. Finally, Mitochondria signal various cellular processes including cell death (apoptosis), gene expressions are turned on or off, and metabolic regulation, primarily through the release of proteins and reactive oxygen species (ROS). They play a crucial role in communicating the health and energy status of the cell to ensure proper functioning. And they have the amazing ability to communicate with their fellow mitochondria.

3. Cells in your body must have a good supply of the ATP/Fuel in order to perform their designed functions for your body.

4a. The number of mitochondria in a cell depends on how much ATP/Fuel the cell needs to produce to do its job. Muscle cells, for example, have many mitochondria because they need to produce energy to move the body. Red blood cells, which carry oxygen to other cells and carbon dioxide away from the cells have none; their transportation activity is passive. Mitochondria are analogous to a furnace or a powerhouse in the cell because, like furnaces or powerhouses, mitochondria produce energy, ATP/Fuel from basic components (in this case, from molecules from foods that have been broken down so that they can be used). A correctly functioning mitochondria uses oxygen in what is called the Krebs cycle to make the ATP from glucose (sugar) in a process that is called the electron transport chain with 4 separate steps explained in the 2 videos below.

4b. https://www.youtube.com/watch?v=mxbodI60OT4&ab_channel=StudyAnimated
4c. https://www.youtube.com/watch?v=2CLfLEUu-1o&ab_channel=JonasKuehneMD

4d. To drill down a little more on the electron transport chain, try this video.
https://www.youtube.com/watch?v=zJNx1DDqIVo&ab_channel=BioManBiology

Can the mitochondria break and NOT produce adequate ATP/Fuel?

1. Yes, and the results are poor performance in terms of the amount of ATP/Fuel produced for the cell.
https://www.youtube.com/watch?v=v5CM573Y1ek&ab_channel=Dr.PaulAnderson

Dr Seyfried – TheBrainwavesVideoAnthology –
Thomas N. Seyfried – Cancer as a Metabolic Disease– This is a MUST VIEW!
​www.youtube.com/watch?v=0OgWi1H-2Zs

2. This leads the cell with broken mitochondria, into sub-performance in terms of its own functions for the cell & body.

3. An essential enzyme, cytochrome c oxidase, used to produce the ATP energy in the 4 part electron transfer chain can become bound by the pollutant, nitric oxide. This then blocks the electron transfer chain from producing adequate amounts of ATP. This lower ATP production leaves the cell with insufficient ATP to perform its duties in the body. Wherever this occurs in the body, cells produce lactic acid that causes a decrease of the pH to the acidic range below 7.0. The whole pH range goes from 1 which is very acidic to 14 which is very alkalotic. 1 is the very acidic end like hydrochloride acid and 14 is the extreme alkalotic range like lye (sodium hydroxide). The body’s chemistry functions best in a very narrow alkalotic window when the blood pH is in the range of 7.35 to 7.45. This is the range in which all the ongoing chemical reactions in your body works best.

4. Several solutions are being suggested to improve ATP production in the mitochondria by breaking the bond between cytochrome c oxidase and nitric oxide which is a pollutant and damaging free radical. This bond can be broken by Methylene Blue (MB) and Red-Light Therapy RLT. Both are covered in more detail later on page 2. When this bond is broken between cytochrome c oxidase and nitric oxide, the electron transport chain can again function fully to produce the needed ATP/Energy which is required for healthy metabolism in each cell.

5. When the pH of the tested urine is brought back up into the alkaline range greater than 7.4 with the use of soda bicarbonate
page 4 (baking soda), the mitochondria have shown to revert back to their normal production of ATP. They begin to produce ATP in adequate amounts for the cell to function according to its originally designed purpose because of the corrected metabolism within the mitochondria in the cells.

Apoptosis
What is it? Apoptosis is the normal, planned death of damaged or worn out cells in your body. It’s an important process that helps keep you healthy. However, if it doesn’t happen often enough, you can develop problems like cancer. Apoptosis is your body’s way of getting rid of damaged or worn out cells through a process called programmed cell death. “Programmed” means your body knows these cells need to die and manages the process from start to finish. Instead of growing and dividing like healthy cells, these cells that go through apoptosis follow a set of steps that lead to their breakdown. Their useful parts are used to build new cells.
Apoptosis is a normal process that supports your health. Your body needs to get rid of cells that are too old or damaged to work properly. If those cells are allowed to remain in the body, they can harm you. Cells with damaged DNA can make copies of themselves and build up inside your body, leading to cancer or other conditions. Apoptosis helps to prevent this from happening.

What is the purpose of apoptosis?
Apoptosis supports your health by clearing out cells your body doesn’t need. It starts before you’re even born. Certain cells die at the right time so different parts of a fetus, like the fingers, can form properly. After birth, apoptosis plays an important role in:
Supporting your body’s constant need to replace old cells with new ones
Helping your immune system fight infections.
Ridding your body of damaged cells that can’t be repaired.
Ensuring that damaged cells don’t multiply.
Supporting balance in your body’s tissues (homeostasis) including burning fat.

Can I naturally promote apoptosis in my body?

​Yes, by trying intermittent fasting defined as extending your time of NOT eating to 16 hours. It’s important to check with your doctor before starting intermittent fasting. You can try a daily or weekly approach, which restricts daily eating to one 8 hour period each day. For instance, you may choose to try 8/16 system: eating in an 8 hour period and fasting for 16 hours. In this case, water or coffee or tea without sugar or cream will NOT break your fast. You could further extend your fast to eating in a 4 hour window and fasting for 29 hours. If you want to go further, you could venture out into 3-day water fast. Seek medical advice if you want to try.

Other triggers to remove broken and worn out cells through apoptosis are The Baking Soda Protocol on Page 4, Iodine on Page 2, Oranges on Page 3, Pomegranate, resistance and endurance exercise.

Movement, Stretching, Breathing, Getting Outside
These actions appear obvious however, in today’s society they need to be much more intentional due to the increased sedentary lifestyles both at work and home.
1. Body movement is crucial for maintaining physical health, as it strengthens muscles and bones, improves cardiovascular function, and reduces the risk of chronic diseases. Additionally, regular movement enhances mental well-being by alleviating stress, anxiety, and depression, while promoting better cognitive function.

2. Stretching the muscles before they’re warmed up can actually hurt them. When everything is cold, the muscle fibers aren’t prepared and may be damaged. If you exercise first, you’ll get blood flow to the area, and that makes the tissue more pliable and amenable to change. All it takes to warm up the muscles before stretching is five to 10 minutes of light activity, such as a quick walk. You can also stretch after an aerobic or weight-training workout. With a body full of muscles, the idea of daily stretching may seem overwhelming. But, it’s most important to focus on the body areas needed for critical for mobility like your lower extremities, your calves, your hamstrings, your hip flexors in the pelvis and quadriceps in the front of the thigh. Stretching your shoulders, neck, and lower back is also beneficial.

Aim for a program of daily stretches, or at least three or four times per week.
Hold a stretch for 30 seconds. Don’t bounce, which can cause injury. You’ll feel tension during a stretch, but you should not feel pain. Stretching once today won’t magically give you perfect flexibility. You’ll need to do it over time and remain committed to the process. It may have taken you many months to get tight muscles, so you’re not going to be perfectly flexible after only a few sessions. It takes weeks to months to get flexible, and you’ll have to continue working on it to maintain it.

3. Breathing Exercises There several different breathing exercises on this website. Take a look and see which ones might be best for you. https://www.verywellhealth.com/breathing-techniques-8382890

4. Simply Get outside to enjoy and drink in your natural surroundings anyway and every day you can.

Stem Cells normal and cancerous
Normal Stem cells are special cells in the body that can develop into different types of cells, such as blood, skin, bone, and muscle cells. They play a crucial role in repairing tissues and maintaining the body’s systems by replacing old, damaged or worn out cells.

Cancer Stem Cells (CSCs) are a specific sub-population of cancer cells that have the ability to self-renew and change into various cell types within a tumor. They are thought to be responsible for tumor growth, metastasis, (spreading of cancer) and relapse after treatment failure due to their unique properties that allow them to survive conventional therapies. CSCs are therefore tumorigenic (tumor generating). CSCs generate tumors through the stem cell processes of self-renewal and differentiation (changing) into many other cell types. When normal stem cells arrive at the site of a cancer tumor to repair it, they are injured by the acid toxic micro-environment of the tumor. Then, rather than repairing the injury causing the cancer to originate in the first place, these newly arriving normal stem cells, because they are injured by the environment, participate in the growth of the tumor, making it even larger and more aggressive.

Several of the options included in this work like Aspirin (Page 3) and Metformin (Page 4) have the potential to stop these stem cell injuries and reduce their participation in the tumor growing process.

Viewing for further information
​P​review YouTube video Mitochondria – the powerhouse of the cell / 3D animated

​Preview YouTube video The Electron Transport Chain Explained (Aerobic Respiration)